Abstract
Serum carnitine values are markedly reduced during dialysis in patients with end-stage renal disease. In an effort to obtain more evidence for dialysis induced carnitine depletion in tissue an antimal model was developed. It was found that a relatively short term peritoneal dialysis treatment in the normal rat led to a 50% decrease in serum carnitine and a 50% reduction of carnitine in the heart and skeletal muscle. The concentration of carnitine in liver did not change. The results indicate that this model may be suitable for determining specific effects of carnitine depletion in heart and skeletal muscle as well as studying the effects of dialysis under various experimental conditions.
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