Dependency of the remnant 131I-NaI biokinetics on the administered activity in patients with differentiated thyroid cancer.

Abstract

To study the dependency of the effective half-life on the administered activity and the correlation between the time-integrated activity and the remnant uptake at 2d and 7d in patients treated for DTC with 1.11GBq, 3.7GBq or 5.55GBq of 131I-NaI. Ninety-two patients undergoing total thyroidectomy and lymph node removal were included. If cancer had not spread to lymph nodes, patients received 1.11GBq of 131I-NaI when the lesion maximal diameter was smaller than 4cm, and 3.7GBq for bigger sizes. If cancer had spread to lymph nodes patients received 5.55GBq. There were 30, 49 and 13 patients respectively treated with 1.11GBq(Group 1), 3.7GBq(Group 2) and 5.55GBq(Group 3). Two SPECT/CT scans were performed at 2d and 7d after radioiodine administration for each patient to determine the thyroid remnant activities and effective half-lives of the radioiodine. Statistical analysis showed significant differences (p<0.05) in the effective half-life among patients treated with 1.11GBq, 3.7GBq and 5.55GBq. A high positive correlation (ρ>0.95) was found between the time-integrated activity and the remnant activity at 2d for the three groups of patients. There were significant differences in the effective half-life of the radioiodine in remnants of patients treated with activities of 1.11GBq, 3.7GBq or 5.55GBq. The high positive linear correlation found between the time-integrated activity and the remnant activity at 2d for the three groups of patients indicate that the time-integrated activity could be estimated from one time-point.