Dependency of Nuclear Deformation of Smooth Muscle Cells on Tissue Stretch Direction May Explain Anisotropic Response of Aortic Wall to Hypertension

Takeo Matsumoto,Eijiro Maeda,Chizuru Hirooka,Naoki Mori,Yong Fan,Junfeng Wang

doi:10.32604/mcb.2019.07102

Abstract

Dependency of Nuclear Deformation of Smooth Muscle Cells on Tissue Stretch Direction May Explain Anisotropic Response of Aortic Wall to Hypertension

Highlights

Many studies reported that the wall thickening occurs to maintain the wall stress in the circumferential direction at a constant level
In case of the longitudinal direction, there are few studies suggesting the constancy of the stress. Such anisotropic response may be attributable to the circumferential alignment of the smooth muscle cells (SMCs) in the wall [1]
To the authors’ knowledge, there are no study discussing the underlying mechanism of the anisotropic response

Summary

Introduction

Aortic wall thickens in response to hypertension. Many studies reported that the wall thickening occurs to maintain the wall stress in the circumferential direction at a constant level. In case of the longitudinal direction, there are few studies suggesting the constancy of the stress.

Results

Conclusion