Abstract
The viability of tissue flaps depends on adequate blood flow and oxygenation. To help ensure oxygen delivery, increased inspired oxygen is often provided. This study uses a porcine model to measure tissue oxygen (TPO2) in a muscle flap, in response to varying levels of inspired oxygen concentration (FiO2). Six swine underwent the creation of a latissimus dorsi island flap. An ultrasonic flow probe was used to monitor afferent flow through the thoracodorsal artery, and a 20-ga fluorescence-quenching optode was employed to monitor TPO2. Additional optodes were inserted in muscle of an ipsilateral hindlimb, and in the terminal ileum. Inspired oxygen concentration was varied from 15 to 100%, and oxygen delivery variables measured. Analysis of variance and multiple linear regression were used to determine which variables had the greatest effect on TPO2. All three sites varied directly with inspired oxygen concentration. Flap TPO2had a strong dependence on FiO2and local oxygen delivery (r2= 0.54). PaO2and hemoglobin were the most significant determinants of ileal submucosal TPO2(r2= 0.65). A correlation between average submucosal and flap TPO2was observed (r> 0.9,P< 0.05). We conclude that (1) muscle flap and bowel TPO2vary directly with inspired FiO2, (2) changes in ileal submucosal TPO2correlate with those observed in muscle, and (3) monitoring of readily accessible muscle TPO2merits further investigation to evaluate the status of TPO2in critical visceral beds.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.