Abstract
SINCE Moinat's1 investigations of haemagglutination antibody titres to insulin, it has been assumed that there is no relationship between insulin requirements and antibody titres except in some cases of insulin resistance. These observations were partly supported by Berson and Yalow2, although these authors did find insulin binding capacities ranging from 50 to 500 units/litre in insulin-resistant patients. Recent investigations in this laboratory3 on variations in insulin requirements in human subjects with differing species of insulin suggested that antibodies to insulin play a significant role in determining insulin requirements even in non-resistant subjects. It was important, therefore, to re-investigate the haemagglutination studies in order to determine whether they reflected a true picture of insulin antibody titres or whether they might be IgM antibody dependent4,5.
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