Abstract
The observed frequency of chromatid aberrations was different at each of three dose rates used in the irradiation of the corneal epithelium of the Chinese hamster. The difference was manifested in the frequency of chromatid deletions as well as chromatid exchanges. When the corneal epithelium was treated with puromycin at the three dose rates, the same frequency of aberrations was observed at all three dose rates. The frequency was the same as that observed at the highest dose rate without treatment with puromycin. Puromycin inhibits protein synthesis, which is known to be necessary for the rejoining of chromosomal breaks. Therefore, it appears that the effect of dose rate is a differential effect on the rejoining system. (P.C.H.)
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