Abstract
AbstractSprague-Dawley rats and Brattleboro rats homozygous and heterozygous for hereditary diabetes insipidus were treated with deoxycorticosterone acetate (DOCA; 100 mg/kg) for periods of up to 2 weeks and the activities of renin in plasma (PRA) and kidney tissue (RRA) were measured. PRA decreased dramatically in all groups within 4 days of DOCA treatment, suggesting that the presence of antidiuretic hormone (ADH) is not necessary for DOCA-induced renin suppression. After 11 and 14 days of treatment, PRA was suppressed less in the homozygous diabetes insipidus rats than in the other two groups, suggesting that the lack of ADH alters the response of PRA to DOCA treatment in the chronic state. RRA was not changed by DOCA treatment in any group, thus demonstrating that the initial response of the renin-angiotensin system to DOCA treatment is a suppression of secretion. These results suggest that the initial response of the renin-angiotensin system to DOCA is not dependent on the presence of ADH.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
