Abstract
Ischemic stroke is a major cause of disability and mortality worldwide, but effective restorative treatments are very limited at present. Regenerative medicine research revealed that stem cells are promising therapeutic options. Dental pulp stem cells (DPSCs) are autologously applicable cells that origin from the neural crest and exhibit neuro-ectodermal features next to multilineage differentiation potentials. DPSCs are of increasing interest since they are relatively easy to obtain, exhibit a strong proliferation ability, and can be cryopreserved for a long time without losing their multi-directional differentiation capacity. Besides, use of DPSCs can avoid fundamental problems such as immune rejection, ethical controversy, and teratogenicity. Therefore, DPSCs provide a tempting prospect for stroke treatment.
Highlights
Specialty section: This article was submitted to Stroke, a section of the journal Frontiers in Neurology
Reported studies showed that the cell diameter of human Dental pulp stem cells (DPSCs) is around 15–16 μm [59], which is comparable to neural stem cell (NSC) [57, 58] but slightly smaller than for most mesenchymal stem cells (MSCs) populations [57, 60] including human bone marrow MSCs (BM-MSCs) [61]
This review summarizes the main DPSC characteristics including surface marker expression, proliferation and differentiation potential, cytokine and trophic factor secretion ability, as well as therapeutic effects in in vitro and in vivo stroke models
Summary
Brain-derived NSCs are considered a promising population for stroke treatment due to their ability to self-renew and to differentiate into neural cells types (neurons, astrocytes, oligodendrocytes) [43]. DPSCs have a higher proliferation rate and a greater clonogenic potential than MSCs [17, 45]. To DPSCs, the DPC population contains a higher number of stem/progenitor cells as compared to bone marrow [50]. This may be attributed to the developmental state of the respective tissues. DPSCs originate from migrating neural crest cells, coming to rest in dental pulp, and express markers overlapping with MSCs, ESCs, and NCSs
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
