Abstract
Acute myeloid leukemia (AML) is the most common type of myeloid malignancy in childhood. In recent years, umbilical cord blood transplantation (UCBT) has emerged as a feasible alternative source of allogeneic stem cell transplantation for patients without HLA-matched marrow donors. Advantages of UCBT are the significantly fast availability, expansion of the donor pool, lower incidence and severity of acute graft-versus-host disease (GVHD), and reduced donor attrition. A 15-year-9-month-old male with AML was referred from the department of pediatric hematology for dental evaluation and management before UCBT. Clinical examination revealed generalized gingivitis, multiple caries and a supernumerary tooth adjacent to #12. Full mouth rehabilitation including periodontal health maintenance care, endodontic treatments, and dental restorations was performed within 3 weeks before UCBT. The patient was then placed on regular dental follow-up after successful transplantation. Early and radical dental intervention reduces the risk for oral and associated systemic complications such as potential infection and mucositis. In-depth knowledge of UCBT will be beneficial to dental clinicians as providing comprehensive management of these patients.
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