Dental Drug Delivery System used in Periodontitis

Abstract

Periodontitis, a condition affecting the teeth’s supporting structures, affects people of all ages, ethnicities, races, and genders. There is a well-established link involving microbial infection and the progression of gum diseases and tooth cavities. There are different types of periodontal diseases caused by microbial infection. Aggressive periodontitis can be localized or generalized. Periodontal infection has been successfully treated with antibacterial medicines. The effectiveness of mechanical plaque debridement and regular use of topical and systemic medicines is limited due to a lack of access to infecting organisms into the periodontal tissues. Systemically administered drugs achieve effective concentration at the infected area, but only for a small period, necessitating multiple doses over extensive periods of time. Antimicrobials delivered locally have being studied to see if they can overcome the limits of conventional therapy. Anti-bacterial is delivered using prolonged release formulations. Anti-bacterial is increasingly being delivered at the infection site (periodontal pocket) through sustained release formulations. This review discusses the main drug delivery system used in periodontal disease, their advantages and evaluations. The usage of collagen dental cones after an infected tooth has been extracted is also discussed in this review. Periodontal regeneration, soft-tissue restoration, and wound healing are all aided by dental cones containing antibacterial and biodegradable polymers.