Abstract
This retrospective pilot study aimed to detect whether remaining dental/periodontal treatment need and periodontal inflammation after dental clearance would be associated with the initial therapy outcome of adult patients with acute leukemia undergoing induction chemotherapy. Different parameters were assessed from the patients' records: initial blood parameters, blood parameters during initial chemotherapy, leukemia/therapy related complaints, duration of fever, microbiological findings (blood and urine), as well as patients' survival. Dental treatment need was defined as the presence of at least one carious tooth; periodontal treatment need was determined by the presence of probing depth ≥3.5 mm in at least two sextants. To reflect periodontal inflammation, the periodontal inflamed surface area (PISA) was applied. Thirty-nine patients were included. A dental treatment need of 75% and periodontal treatment need of 76% as well as an average PISA of 153.18 ± 158.09 were found. Only two associations were detected: periodontal treatment need was associated with thrombocyte count after 7 days (p=0.03), and PISA was associated with erythrocyte count three days after induction of therapy (p=0.01). It can be concluded that remaining dental and periodontal treatment need as well as periodontal inflammation after dental clearance is not associated with the outcome of induction therapy in adult patients with acute leukemia.
Highlights
Acute leukemia is a highly progressive and severe disease which takes a fatal course if no appropriate treatment is applied [1]. ereby, induction chemotherapy is still the standard therapy for the majority of affected patients [2]
Between January 2015 and April 2015, hospitalized patients suffering from acute leukemia in the Clinic of Hematology and Oncology of the University Medical Center Goettingen to receive induction chemotherapy were recruited. e assessment of clinical oral parameters was performed by one experienced dentist in course of the previous cross-sectional study [14]
A mandatory condition for participation in the current study was a history of induction chemotherapy because of acute leukemia in the Clinic of Hematology and Oncology of the University Medical Center Goettingen
Summary
Acute leukemia is a highly progressive and severe disease which takes a fatal course if no appropriate treatment is applied [1]. ereby, induction chemotherapy is still the standard therapy for the majority of affected patients [2]. Ereby, induction chemotherapy is still the standard therapy for the majority of affected patients [2]. This therapeutic intervention is often the only chance to save patients’ life, infectious complications caused by the immunosuppressive effect of chemotherapy are a major problem, leading to increased mortality [3]. As one potential entry point of bacteria in the blood, the oral cavity and related infectious diseases are of relevance as an important source of bacteraemia [4]. The dental clearance prior to chemotherapy is a regular recommendation [5, 6]. A delay in anticancer therapy caused by dental rehabilitation should be avoided [6]. ese factors are important limitations of possible dental surgical
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