Abstract
Serotonin-1A receptor antagonists and serotonin-2A receptor agonists have in several studies been shown to have neuroprotective properties in roden models of cerebral ischemia A quantitative autoradiographic study was made to determine the density of serotonin-1A and serotonin-2A receptors in rat brain subjected to 10 minutes of global cerebral ischemia. The ischemic group and control group was sacrificed 24 hours after the ischemic attack. In the ischemic group of rats the density of serotonin-1A receptors was reduced in ventral dentate gyrus, lateral reticular thalamic nucleus and cortex compared to the control group. The changes in the lateral reticular thalamic nucleus and in cortex can be explained as a reflection of cell loss in these areas. However, the reduction in ventral dentate gyrus is unrelated to cell loss detected by eosin-hematoxylin staining. No changes between the to groups was seen for the serotonin-2A receptor.
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