Density distribution of 51CR-labelled platelets within the circulating dog platelet population

Abstract

The density distribution of 51Cr-labelled platelets was studied in a linear colloidal silica-polyvinylpyrrolidone density gradient and compared with the density distribution of the circulating platelet population. Twenty-four, 48 and 72 hours after labelling of the platelets close correspondence was found between the density distribution of the label and the platelets, These results seem to justify the use of 51Cr-labelled platelets for turnover studies and for quantitation of platelet deposition in various organs as well as in experimental thrombi.