Abstract
The number of active sweat glands was observed in patients with cystic fibrosis and healthy, age-matched controls following stimulation of sweating on the inner forearm surface by pilocarpine iontophoresis. Though gland density appeared to be higher and more variable in cystic fibrosis, statistical analysis of this relationship was inconclusive but did not allow a rejection of the hypothesis that patients have higher gland densities at a given age than controls. The amount of sweat produced in cystic fibrosis was related to the number of active glands; this was not true of controls. The parameter of gland density, added to the previously described sweat test procedure, has allowed calculation of the average sweat output per gland on the forearm. This output increased with increasing age in both controls and patients with cystic fibrosis.
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