Abstract

Summary A simple and rapid densitometric method has been developed for determination of desloratadine in tablets. After extraction of the samples with 96% ethanol the solutions were spotted on precoated silica gel TLC plates and these were eluted with ethyl acetate– n-butanol–25% aqueous ammonia–methanol, 21 + 5.0 + 4.0 + 5.0 (v/v), as mobile phase. Quantitative evaluation was performed by measuring the absorbance reflectance of the desloratadine spots at λ = 279 nm. The TLC–densitometric method is selective, precise, and accurate and can be used for routine analysis of tablets in pharmaceutical industry quality control laboratories.

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