Abstract
Microgoblet laser pairs are presented for cross-referenced on-chip biomolecular sensing. Parallel readout of the micro-lasers facilitates effective mutual filtering of highly localized refractive index and temperature fluctuations in the analyte. Cross-referenced detection of two different types of proteins and complete chemical transducer reconfiguration is demonstrated. Selective surface functionalization of the individual lasers with high spatial accuracy is achieved by aligned microcontact stamping.
Highlights
A sole temperature referencing can be performed with one single WGM transducer, but requires rather complex transducer preparation methods and well controlled high resolution WGM readout schemes.[1,15]
Defined cavity configurations can be realized, with each individual resonator exhibiting a distinct set of WGMs
In this work we present a sensing platform for facile crossreferenced detection of multiple different molecules
Summary
A sole temperature referencing can be performed with one single WGM transducer, but requires rather complex transducer preparation methods and well controlled high resolution WGM readout schemes.[1,15] Still, signal disturbances from refractive index fluctuations or nonspecific molecular binding can solely be filtered out by the use of at least one additional reference transducer. To demonstrate the referencing capability of the microlaser pairs, we performed a molecular detection experiment mimicking these typical signal disturbances (Figure 3).
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