Abstract
Backgrounds: Dengue viruses are transmitted to humans via mosquito bites from infected Aedes species (Aedesaegypti or Aedesalbopictus). Dengue fever affects over half of the world's population, or about 4 billion people. Dengue fever is a common cause of sickness in high-risk settings. Methods: In the current study two serotypes of Dengue viruses namely DENV1 and DENV2 taken for the study. Here two important compounds namely Ellagic acid and Ferric Carboxymaltose chosen for the targets to be inhibited. In silico docking approach performed to dock the two compounds against the DENV1 and DENV2 viruses of Dengue. Autodock 4.2 tool chosen for the docking purpose. Results: Dengue i.e., DENV-1 & 2 indicate excellent biding property with Ellagic Acid & Ferric Carboxymaltose of the order -6.02 kcal/mol& -6.9 kcal/mol, respectively. Either are hematinic; pregnancy safe; non-toxic; complete synergy between either vis-à-vis virus targets\binding sites; with supportive therapies; etc. Novel. It was found that, the Ellagic acid is more effective for DENV1 virus and Ferric kcal/mol, respectively. Conclusions: It can be stated that, these two drugs can be better approach for future study against the Dengue viruses and expected drug candidates.
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