Abstract
Dengue Virus Type 3, Cuba, 2000–2002
Highlights
Pacific/Asian group; 2) an Asian group, containing a large array of viruses sampled from Thailand and Malaysia; 3) a Latin American group that includes the Cuban viruses and isolates from Venezuela, Martinique, and Nicaragua, as well as those from Samoa, India, and Sri Lanka; 4) a small group of Asian viruses; and 5) a final, most divergent group containing virus samples from Puerto Rico
Strain D3.Nicaragua.24/94 falls at the base of the Latin American clade within genotype III, as would be expected if it was the first dengue virus type 3 (DENV-3) strain isolated from this region in 1994
The current study strongly suggests that an Asian DENV-3 virus assigned to genotype III has evolved in situ in the Caribbean region since 1994
Summary
The tree (Figure) showed 5 major groups or genotypes of DENV-3: 1) a Figure. Maximum likelihood (ML) phylogenetic tree showing the evolutionary relationships among the E gene sequences of 64 strains of DENV-3. Pacific/Asian group (genotype I); 2) an Asian group, containing a large array of viruses sampled from Thailand and Malaysia (genotype II); 3) a Latin American group that includes the Cuban viruses and isolates from Venezuela, Martinique, and Nicaragua, as well as those from Samoa, India, and Sri Lanka (genotype III); 4) a small group of Asian viruses (genotype IV); and 5) a final, most divergent group containing virus samples from Puerto Rico (genotype V).
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