Abstract
Dengue virus infections are increasing worldwide generally and in Asia, Central and South America and Africa, particularly. It poses a serious threat to the children population. The rapid and accurate diagnostic systems are essentially required due to lack of effective vaccine against dengue virus and the progressive spread of the dengue virus infection. The recent progress in developing micro- and nano-fabrication techniques has led to low cost and scale down the biomedical point-of-care devices. Starting from the conventional and modern available methods for the diagnosis of dengue infection, this review examines several emerging rapid and point-of-care diagnostic devices that hold significant potential for the progress in smart diagnosis tools. The given review revealed that an effective vaccine is required urgently against all the dengue virus serotypes. However, the rapid detection methods of dengue virus help in early treatment and significantly reduce the dengue virus outbreak.
Highlights
The dengue virus (DENV) belongs to the Flavivirus genus to the Flaviviridae family and is transmitted from Aedes spp. mosquitoes to humans
The antigen-based assays have been proven to be useful for the detection of the dengue non-structural protein 1 (NS1) protein
The rapid detection of dengue virus is essential at an early stage due to the unavailability of treatment and any reliable vaccine for dengue infection
Summary
The dengue virus (DENV) belongs to the Flavivirus genus to the Flaviviridae family and is transmitted from Aedes spp. mosquitoes to humans. The increase in dengue virus infection among various countries has led to developing a rapid and miniaturized point-of-care (POC) test for dengue diagnosis (Jain et al, 2021). Serological Tests DENV diagnostic devices must diagnose the infection at an early stage These methods must be designed to detect the DENV antigen or antibodies. The dengue virus and its associated components such as RNA or NSI antigens are detectable in serum, plasma, blood cells, and infected tissues within 1–2 days following infection up to 9 days with symptoms appearance (Flipse et al, 2016; St. John and Rathore, 2019). The diagnosis is based on detecting the host immune response caused by dengue infection. The. DENGUE VIRUS INFECTION: A REVIEW OF ADVANCES IN THE EMERGING RAPID DETECTION METHODS 63
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