Dengue fever transmission between a construction site and its surrounding communities in China

Zeyu Zhao,Tie Song,Jia Rui,Tianmu Chen,Xiqing Huang,Qu Cheng,Xingchun Liu,Meng Zhang,Roger Frutos,Guoqiang Ye,Min Kang,Yingtao Zhang,Qingqing Hu

doi:10.1186/s13071-020-04463-x

Abstract

BackgroundDue to an increase in mosquito habitats and the lack facilities to carry out basic mosquito control, construction sites in China are more likely to experience secondary dengue fever infection after importation of an initial infection, which may then increase the number of infections in the neighboring communities and the chance of community transmission. The aim of this study was to investigate how to effectively reduce the transmission of dengue fever at construction sites and the neighboring communities.MethodsThe Susceptible-Exposed-Infectious/Asymptomatic-Recovered (SEIAR) model of human and SEI model of mosquitoes were developed to estimate the transmission of dengue virus between humans and mosquitoes within the construction site and within a neighboring community, as well between each of these. With the calibrated model, we further estimated the effectiveness of different intervention scenarios targeting at reducing the transmissibility at different locations (i.e. construction sites and community) with the total attack rate (TAR) and the duration of the outbreak (DO).ResultsA total of 102 construction site-related and 131 community-related cases of dengue fever were reported in our area of study. Without intervention, the number of cases related to the construction site and the community rose to 156 (TAR: 31.25%) and 10,796 (TAR: 21.59%), respectively. When the transmission route from mosquitoes to humans in the community was cut off, the number of community cases decreased to a minimum of 33 compared with other simulated scenarios (TAR: 0.068%, DO: 60 days). If the transmission route from infectious mosquitoes in the community and that from the construction site to susceptible people on the site were cut off at the same time, the number of cases on the construction site dropped to a minimum of 74 (TAR: 14.88%, DO: 66 days).ConclusionsTo control the outbreak of dengue fever effectively on both the construction site and in the community, interventions needed to be made both within the community and from the community to the construction site. If interventions only took place within the construction site, the number of cases on the construction site would not be reduced. Also, interventions implemented only within the construction site or between the construction site and the community would not lead to a reduction in the number of cases in the community.Graphical

Highlights

Dengue fever (DF) is one of the most rapidly spreading mosquito-borne diseases in the world
We considered the case reported on August 17 in Zhanjiang Prefecture as the index case in our study area, given the facts that: (1) the extrinsic incubation period of DF is about 10 days [21] and the time interval between this case and the first case in our study area on the construction site A on August 27 falls into the typical range of the serial interval of dengue; (2) this case lives in Community B, Chikan District, which is < 1 km away from the construction site A; (3) the case visited the construction site several times before August 27
Model structure We developed a model to simulate the transmission of dengue virus within the residential areas, on construction site A located in Community A, and between the residential areas and construction site A

Summary

Introduction

Dengue fever (DF) is one of the most rapidly spreading mosquito-borne diseases in the world. The rapidly increasing rate of urbanization has provided the Aedes mosquito with many new breeding sites, and this increase in breeding sites has become important risk factor for DF Containers, such as waste containers, tires and water storage tanks, are major sites of Aedes mosquito breeding [7], with increased population density and mobility facilitating the propagation of the virus [2, 8]. These environmental conditions and the lack of basic mosquito control facilities have made construction sites in high-risk areas hotspots for outbreaks. The aim of this study was to investigate how to effectively reduce the transmission of dengue fever at construction sites and the neighboring communities

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Discussion

Conclusion