Dengue and Dengue Hemorrhagic Fever

Abstract

An estimated 50 to 100 million cases of dengue fever (DF) and several thousand cases of dengue hemorrhagic fever (DHF) occur each year. Having a case fatality rate of about 5%, DHF has become one of the most important vector-borne viral diseases in the world. This book provides one-stop shopping for what is known about this Flavivirus, its 4 antigenically related but distinct serotypes, the Aedes mosquito vector, and its human pathogenesis. Chapters 5, 6, and 7 get to the heart of the clinical spectrum and pathology of DF and DHF. The chapters include information about diagnosis, management, classification of DHF, and indications for hospitalization. The flow diagrams for critical management decisions are excellent. Public health information officers, practicing clinicians, biomolecular geneticists, emporiatricians, immunohistopathologists, and pharmaceutical research scientists will all find their areas of interest discussed in the book, with more besides. RNA sequencing, envelope protein properties, immune response, clinical spectrum of disease, evaluation, treatment, vaccine research and development, dengue surveillance, and vector control programs are all covered in detail. If all you want is a passing knowledge of DF and DHF, this book might not be for you. However, if you want to recognize and treat DF, DHF, and dengue shock syndrome with a substantial knowledge base, and if you want to be fully prepared for the rising dengue pandemic, this book is just what the doctor ordered.