Abstract
The effect of denervation on the skeletal muscle resting membrane potential (RMP) was studied in the soleus muscle of the intact rat. The RMP decreased much later than reported in previous in vitro studies. With a very short nerve stump (less than 2 mm), the RMP began to decrease 18 h after denervation and 4 h after miniature end-plate potentials ceased. With a longer nerve stump (39 to 43 mm) the decrease in RMP was delayed about 3 h. Our findings in vivo fail to confirm previous arguments against a role for acetylcholine in regulating the muscle RMP. The influence of usage and the possible effects of spontaneous quantal and nonquantal acetylcholine release or other hypothetical factors are discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
