Dendronised Ni(ii) porphyrins as photoswitchable contrast agents for MRI.

Marcel Dommaschk,Christian Riedel,Jan-Bernd Hövener,Jens Gröbner,Vanessa Wellm,Rainer Herges

doi:10.1039/c9cp04156g

Abstract

Light-responsive contrast agents for magnetic resonance imaging (MRI) based on Ni(ii) porphyrin molecular spin switches have recently been introduced. We present their implementation in water and methanol based gels leading to the first soft materials that are rewritable with light and readable with MRI. Light of two different wavelengths as non-invasive stimuli can be applied to switch MRI contrast on and off, with a high spatiotemporal resolution and without fatigue.

Highlights

Marcel Dommaschk, a Jens Grobner,a Vanessa Wellm, a Jan-Bernd Hovener, b Christian Riedelc and Rainer Herges *a
Light-responsive contrast agents for magnetic resonance imaging (MRI) based on Ni(II) porphyrin molecular spin switches have recently been introduced. We present their implementation in water and methanol based gels leading to the first soft materials that are rewritable with light and readable with MRI
We report on the synthesis and investigation of molecular spin switches in aqueous solution, as well as in methanol and water based gels

Summary

Introduction

Marcel Dommaschk, a Jens Grobner,a Vanessa Wellm, a Jan-Bernd Hovener, b Christian Riedelc and Rainer Herges *a. Light-responsive contrast agents for magnetic resonance imaging (MRI) based on Ni(II) porphyrin molecular spin switches have recently been introduced. We present their implementation in water and methanol based gels leading to the first soft materials that are rewritable with light and readable with MRI.

Results

Conclusion