Dendrobii Officinalis Flower improved learning and memory impairment by mediating antioxidant effect in Senescent Rats

Abstract

Aging is a necessary process, with the main feature of structural and functional decline, adaptability and resistance weakened, accompanied with obvious feature of memory dysfunction. At present, the aging of population has become the basic situation in China. Elderly people aged over 60 had reached 130 million in the year of 2007, accounting for 10% of the total population. It is expected that to 2020 year, the aging population will reach 2.24 to 3 million. To the year of 2050, 60 years of age will be more than 400 million. Therefore, it is important to study methods to delay senility to improve the quality of life of elderly and prevent and control the incidence of senile diseases.Dendrobii Officinalis Flower (DOF), which is belong to Dendrobium officinale, is very popular to people for the effect of anti‐aging in China, but lack of corresponding pharmacological experiments. The aim of was to evaluate whether DOF has effect on antioxidant enzymes and improving the brain function in aging rats. DOF was administrated at a dosage of 1.38, or 0.46 g · kg−1 once a day, as well as with a normal control group and senescent control group for 8 weeks. The results showed that DOF could improving the learning function of the escape latency, total distance and target quadrant time at 1.38 g · kg−1 and 0.46 g · kg−1 in Morris water maze experiment, as well as increasing level of γ‐GABA. In addition, DOF (1.38 g · kg−1) could decrease the levels of MDA, Glu and MAO‐B, improving locomotors, SOD and GSH‐P x. Histopathological study showed DOF also could significantly reduce structural lesions and neurodegeneration in the hippocampus. In conclusion, DOF could alleviate brain aging and ameliorate the bodily functions, which may be due to attenuating body's oxidative stress, improving hippocampus damage, and balance the release of neurotransmitters.Support or Funding InformationThis study was supported by the National Key Research and Development Program (No. 2017YFC1702200), the National Science Foundation of China (No. 81673638, No. 81874352, No. 81703772 and No.81803760), the China Postdoctoral Science Foundation (No. 2018M632506)This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.