Dendritic polymers based on poly(ethylene glycol) -co- poly(glycolic acid) -co- methacrylate and 2.0 G -polyamidoamine- metharylamide: Design, characterization, and in vitro degradation, and drug release properties

Abstract

In this paper, the properties of the complete degradation process of newly synthesized multi-block 2.0 G-polyamidoamine-double bond (PAMAM-DB) and resoluble poly (ethylene glycol) -co- poly (glycolic acid) -co- methacryloyl chloride (PEG-co-PGA-co-DB, 4KG5-DB) macromonomers were reported. Rectangular shaped samples were prepared by crosslinking the components using both chemical and photo initiators and exposure to UV light. The aims of the study were to examine the effects of the vitro degradation and drug delivery of the crosslinking group on the properties of photocrosslinked hydrogels. The experimental variable was PAMAM-DB: 4KG5-DB ratio. The effects of this variable on local PH, water uptake, mass loss, and drug release were explored. Polymers were characterized by 1H NMR, 13C NMR, FT-IR, and SEM. Our study revealed that polymers with 40%, 50%, 60% 4KG5-DB (mass fraction) showed more excellent mechanical properties, 40% also showed outstanding vitro degradation properties. In vitro drug release, however, 60% drug released mechanism seemed to approach the Fickian diffusion and possessed more excellent drug release properties compared with formulation 40% and 50%. In general, an increase ratio of 4KG5-DB led to a higher density of tree-like polymer which resulted in slower of degradation and drug release. Incorporation of 4KG5-DB into the polymer was critical for maintaining integrity and increasing hydrophilicity during degradation. These results obtained suggest that this system could be potential as a material for bone replacement and controlled delivery of drugs.