Abstract
Meeting abstracts iNKT cells are CD1d-restricted T cells that are rapidly activated in response to antigen and play a key role in promoting adaptive anti-tumor immunity. Surprisingly, we found that mice bearing 4T1 breast cancer CD8+ T cells inhibited spontaneous metastases in the absence of iNKT
Highlights
INKT cells are CD1d-restricted T cells that are rapidly activated in response to antigen and play a key role in promoting adaptive anti-tumor immunity
Dendritic cells cross-presenting tumor-derived antigens are eliminated by invariant natural killer T cells, impairing development of anti-tumor immunity to a mouse carcinoma
We found that mice bearing 4T1 breast cancer CD8+ T cells inhibited spontaneous metastases in the absence of invariant natural killer T (iNKT) cells, suggesting that iNKT cells were suppressing the onset of CD8 + anti-tumor T cell responses. iNKT-deficient mice showed a markedly improved response to treatment with local radiotherapy (RT) and anti-CTLA-4 antibody (Pilones et al, Clin Cancer Res 2009)
Summary
INKT cells are CD1d-restricted T cells that are rapidly activated in response to antigen and play a key role in promoting adaptive anti-tumor immunity. Dendritic cells cross-presenting tumor-derived antigens are eliminated by invariant natural killer T (iNKT) cells, impairing development of anti-tumor immunity to a mouse carcinoma We found that mice bearing 4T1 breast cancer CD8+ T cells inhibited spontaneous metastases in the absence of iNKT cells, suggesting that iNKT cells were suppressing the onset of CD8 + anti-tumor T cell responses.
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