Abstract
To the Editor: Localized granuloma annulare (GA) is a common dermatosis characterized by annular patches and plaques without scale.1 Although GA was initially described more than 100 years ago,2 it remains poorly understood, with no known origin or pathogenetic mechanism. Since its earliest descriptions, GA has been believed to be a disorder of histiocytes, because dermal palisaded histiocytoid cells surrounding acellular regions with collagen and mucin intermixed are seen on skin biopsy specimen.
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