Abstract
Dendritic cells (DC) represent heterogenous populations of bone marrow-derived cells that have central roles in the initiation and regulation of immune responses (reviewed in Steinman 1991). The cells under consideration are quite distinct from the follicular DCs found in B-cell areas of lymphoid tissues. It is, however, now clear that there is not a single DC lineage, but that cells with DC properties may arise from at least three lineages and can exist in different states of maturation and activation. The relationships between these lineages and their functional significance in immune responses are far from clear.
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