Abstract
Regulatory T (Treg) cells protect damaged tissues but can undermine the effects of cancer treatments, including radiation (RTx). Intratumoral immuno-stimulatory dendritic cells (cDC1) respond to RTx with production of Treg-attracting MDC/CCL22, undermining RT effects. That effect can be reversed by EGFR-targeted IFNa, highlighting cDC1 plasticity and relevance as therapeutic targets.
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Schedule a callMore From: Clinical cancer research : an official journal of the American Association for Cancer Research
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