Abstract
Orthodromic responses after local field stimulation were studied in a neostriatal slice preparation. Single suprathreshold stimuli evoked slow plateau-like orthodromic responses with repetitive firing and duration proportional to the stimulus intensity. Its persistence and apparent threshold upon hyperpolarization, as well as the actions of tetraethylammonium, QX-314 and Sr 2+, suggest that this orthodromic response and associated phenomena such as fast prepotentials or Ca-dependent action potentials, may be generated on dendrites.
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