Abstract

Dendrimer Nanoparticles Conjugated 99mTC as a Promising Bioimaging Probe

Highlights

  • Nuclear medicine agentsIn the field of Nuclear Medicine procedures, radio-pharmaceuticals are administered to the patients and their radiations are detected by sensors

  • We focused on a wide range of applications of linker molecules for increasing signal-to-noise ratios (SNR) correlated with images

  • Other trials carried out by Shen et al [39] by involving the G5 PAMAM dendrimers functionalized at the primary amines periphery with DTPA as a 99mTc-ligand and folic acid (FA) as a targeting agent for folate receptors over-expressed in cancer cells [40]

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Summary

Introduction

Nuclear medicine agentsIn the field of Nuclear Medicine procedures, radio-pharmaceuticals are administered to the patients and their radiations are detected by sensors. Scintigraphy imaging detects the emission of the tracer in a planar form, whereas in Single Photon Emission Tomography (SPECT), the gamma camera detects and reconstructs the tracer emissions as 3D images [2]. Innovative modalities such as Positron Emission Tomography (PET) uses compounds labeled with positron-emitting radionuclides to provide functional images. Dendrimers in the field of nuclear medicine have concentrated on improving the primary diagnosis of tumors and on their treatment. As a challenge in Nuclear Medicine, both SPECT and PET are limited by a low spatial resolution. We focused on a wide range of applications of linker molecules for increasing SNR correlated with images

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