Abstract
For the first time, a new type of pH/thermosensitive polymer was synthesized with allyl alcohol and N-vinylcaprolactam on the tungsten disulfide surface. The dendrimer was grown from the surface of the modified tungsten disulfide as a nanocarrier to encapsulate the capecitabine. The obtained nanoparticles were characterized using different techniques. Various types of parameters were optimized. Drug release experiments were performed at different temperatures and pHs. To address these issues, a near-infrared laser irradiation drug delivery system was developed. The release rate of capecitabine from nanocarrier at pH 5.6 was remarkably higher than that at pH 7.4. The nanocarrier could release more than 90% of the drug at 45 °C in pH = 5.6 within 6 h. The release curves of drug from nanocarrier revealed strong dependences on near-infrared laser irradiation. This study aimed to evaluate the cytotoxicity of pH/thermosensitive nanocarrier through MTT assay against MCF-7 breast cancer and normal breast cells. The MTT assay indicated that the pH/thermosensitive nanocarrier significantly increased the rate of cell death in MCF-7 breast cancer cell line when compared to normal breast cells. The results revealed that pH/thermosensitive nanocarrier can be used as controlled drug delivery systems for breast cancer cells. The synthesized nanocarrier are a promising candidate for controlled release of capecitabine.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.