Abstract
Demyelination and neurodegenerative changes in serum IgG antibodies to GM1, GD1a and GM3 gangliosides in a patient on dialysis
Highlights
Patients with renal failure may manifest a variety of neurologic disorders.despite the adequate maintenance dialysis therapy, some patientscontinue to be afflicted with more subtle nervous dysfunction, including impaired mentation, generalized weakness, and peripheral neuropathy
The dialytic treatment of end-stage renal disease has itself been associated with the emergence of several new disorders of the central nervous system: dialysis dysequilibrium, dialysis dementia and progressive intellectual dysfunction
In addition to the foregoing neurologic diseases which are related to uremia and/or dialysis, a number of other neurologic disorders occur with increased frequency in patients with end-stage renal disease on chronic hemodialysis
Summary
Patients with renal failure may manifest a variety of neurologic disorders.despite the adequate maintenance dialysis therapy, some patientscontinue to be afflicted with more subtle nervous dysfunction, including impaired mentation, generalized weakness, and peripheral neuropathy These central nervous system disorders are referred to as uremic encephalopathy. In addition to the foregoing neurologic diseases which are related to uremia and/or dialysis, a number of other neurologic disorders occur with increased frequency in patients with end-stage renal disease on chronic hemodialysis. These include subdural hematoma, electrolyte disorders, vitamin deficiencies, drug intoxication, hypertensive encephalopathy, and acute trace element intoxication [1,2,3]. Some time ago we conducted an experiment in animals, which proves intoxication affects glial cells
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