Demonstration program of population-based lung cancer screening in China: Rationale and study design.

Qinghua Zhou,Weimin Li,Jiewei Liu,Yaguang Fan,Xinyun Wang,Lu Li,Yunchao Huang,Ning Wu,Ying Wang,Youlin Qiao

doi:10.1111/1759-7714.12078

Abstract

BackgroundLung cancer is the leading cause of cancer-related death and has become an enormous economic burden in China. Low-dose spiral computed tomography (LDCT) screening could reduce lung cancer mortality. The feasibility of conducting a population-based lung cancer screening with LDCT in China is uncertain.MethodsIn 2010, a demonstration program of lung cancer screening was initiated in China. High-risk individuals were enrolled in a cluster sampling design in different centers. Participants received baseline and annual screening with spiral CT and follow-up information was collected. The objective of this program is to evaluate the feasibility of conducting population-based LDCT lung cancer screening in the Chinese context. The rates of detection, early diagnosis and treatment are defined as indicators of program performance. The optimal management strategies for nodules are explored in the Chinese context based on experiences in other studies overseas.ResultsA demonstration program of ongoing prospective, multi-center, population-based lung cancer screening is being performed in China.ConclusionsThis demonstration program will provide opportunities to explore the feasibility of LDCT lung cancer screening in the Chinese setting.

Highlights

Lung cancer is the leading cause of cancer-related death worldwide.[1]
Several risk factors, including smoking, involuntary smoking, occupational exposure, indoor radon, genetics, and previous lung disease contribute to lung cancer death.[4,5,6,7,8,9,10,11]
Participants with high lung cancer risk are enrolled based on a cluster sampling design

Summary

Introduction

Lung cancer is the leading cause of cancer-related death worldwide.[1] In China, according to Third National Death Survey conducted in 2004–2005, lung cancer mortality has increased 465% during the past 30 years.[2] Lung cancer has become an enormous economic burden in China. Lung cancer is the leading cause of cancer-related death and has become an enormous economic burden in China. Tianjin Lung Cancer Institute, Tianjin Medical Methods: In 2010, a demonstration program of lung cancer screening was initiated. The rates of detection, early diagnosis and treatment are defined as Youlin Qiao, Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical indicators of program performance

Methods

Discussion

Conclusion