Abstract
Comparatively high doses of muscimol induces myoclonic jerks in a particular strain of mice. 1-Hydroxy-3-amino-pyrrolidone-2 (HA-966) in doses of 1–10 mg/kg caused a dose-dependent blockade of this response of muscimol. Our earlier studies showed that the muscimol-induced myoclinic jerks fulfill certain criteria necessary to be considered as a valid animal model for postanoxic action myoclonus. On this basis it was concluded that HA-966 might prove to be of value in the management of this disorder.
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