Abstract
1. 1. Salmon calcitonin binding by isolated gill cells from rainbow trout, Salmo gairdneri has been investigated. 2. 2. The calcitonin receptor interaction is time- and temperature-dependent. 3. 3. 50% of inhibition of the 125I labeled calcitonin binding is observed in presence of 1.5 ng/ml unlabeled salmon calcitonin. 4. 4. Two types of receptors are described: a high affinity-low capacity site and a low affinity-large capacity site. 5. 5. These studies strongly support the role of calcitonin as a hormone regulating the gill function in physiological conditions.
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