Abstract
During the investigation into the possibility of purifying an API intermediate from a dimeric impurity via organic solvent nanofiltration (OSN). A change in rejection profile was noted on the addition of a strong acid to a solution of the amine in the mixed solvent system of tetrahydrofuran–water (80:20). This change in rejection did not occur with the impurity, thus making the separation via OSN far more effective. The requirement of all three components i.e. acid, organic solvent and water to achieve this change in rejection was also demonstrated. Additionally the type of acid, quantity and the effects of the acidic solution on membrane stability were also examined.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
