Abstract
Tumour transplant immunity studies in hamsters demonstrated a transplantation antigen in CELO tumour cells. The transplant immunity was apparently virus specific since hamsters immunized with CELO virus did not reject transplants of SV40 induced hamster tumour cells. Immunofluorescence studies indicated the presence of a CELO virus tumour antigen in serially cultured tissue culture cells derived from a CELO induced hamster tumour. The antigen was located in the cell nuclei, and could not be detected in the cytoplasm. CELO virus has several properties which may make it a useful model virus for studies of viral oncogenesis.
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