Abstract
The effects of human autopsy skin and liver extracts were studied on mitotic incidence in cultures of human epidermal cells. Whereas skin extracts inhibited mitosis significantly, liver extract had no effect. Neither skin nor liver extract had a significant inhibitory effect on mitosis of monkey kidney cells in vitro . These results demonstrate that the mitotic inhibitory effects of the skin extracts are tissue specific. The evidence also indicates that skin extracts act directly on the epidermal cells, a point which has not previously been demonstrated. Thus, human skin contains tissue-specific mitotic inhibitory factors similar to those described in non-human tissues.
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