Demography of vascular Behcet\u2019s disease with different gender and age: an investigation with 166 Chinese patients

Yong Chen,Jian-Fei Cai,Jian-Long Guan,Chen-Hong Lin

doi:10.1186/s13023-019-1061-1

Abstract

BackgroundThe Clinical features of vascular Behcet’s disease (BD) are not well understood because there are few studies. Our study aimed to investigate characteristics of vascular BD in both genders in different age groups.ResultsWe enrolled 923 patients with BD who presented to our hospital with adequate medical histories and proper vascular screening exams. The raw incidence rate of vascular BD was 17.98% (166/923). The ratio of vascular BD in male to female patients was 1.868 (p = 0.0004, 95% confidence interval (CI): 1.317 to 2.625). There was a tendency towards higher ESR and CRP in vascular BD patients than in mucocutaneous, but the difference was not significant. The most susceptible affected vessels were cerebral (29.6% in males, 59.4% in females) and lower limb vessels (31.2% in males, and 17.2% in females). The incidence of vascular involvement in younger (< 50 years old) and older (≥ 50 years old) patients were similar, with ratios of 16.58% (122/736) and 23.53% (44/187) respectively. However, in females, younger patients were less likely to have vascular involvement than were older patients (11.43% vs. 20% p = 0.0328, OR: 0.5161, 95% CI: 0.2874 to 0.912). Aneurysm or pseudoaneurysm was diagnosed in 1.84% (17/923) patients, mostly in male patients (p < 0.05, OR: 3.221, 95% CI: 1.097 to 9.112). Twenty vascular BD patients were followed up, and the age at BD diagnosis was 33.23 ± 11.56 year. This did not differ statistically with their age at vascular involvement (36.15 ± 9.52 years). Ages of vascular BD patients did not differ significantly from those of mucocutaneous BD patients (n = 143) in both males and females.ConclusionVascular BD, including lethal types of aneurysm is more likely to occur in male patients. The female patients has a similar incidence rate with the males in their postmenopausal age. There was no evidence of progression course from mucocutaneous BD to vascular involvement.

Highlights

The Clinical features of vascular Behcet’s disease (BD) are not well understood because there are few studies
Fisher’s exact test indicated odds ratio (OR) for vascular BD in male to female patients was 1.868 (p = 0.0004, 95% CI: 1.317 to 2.625) (Fig. 1a)
Results from our institution were in accordance with those of previous studies in that males were more susceptible to vascular involvement than were females. (OR: 1.868, p = 0.0004, 95% CI: 1.317 to 2.625)

Summary

Introduction

The Clinical features of vascular Behcet’s disease (BD) are not well understood because there are few studies. Behcet’s disease (BD) is a vasculitis, manifesting as a chronic, relapsing autoinflammatory disorder. It is characterized by oral and genital ulcerations with uveitis, as well as other clinical manifestations in multiple organ systems [1]. The incidence of vascular involvement in BD is reported to be in the. Because BD is a rare disorder and BD with vascular involvement is regarded as an orphan disease. Apart from some case reports, there are few clinical studies of vascular BD published. To better understand vascular BD, we retrospectively investigated 166 cases of vascular BD in 923 BD patients from China

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Discussion

Conclusion