DEMOGRAPHY OF CYSTIC FIBROSIS AT A KASHMIRI SPECIALTY HOSPITAL

Abstract

INTRODUCTION Cystic brosis (CF) is a recessive genetic disorder caused by a mutation in the epithelial chloride channel—CFTR (CFTR). Our study's primary objective was to examine the demographic prole of cystic brosis at our specialised hospital. MATERIAL AND METHODS The current research was a hospital-based observational study of individuals suspected of having cystic brosis undertaken at the G.B. Pant Children's Hospital in Srinagar between 2019 and 2022. In this research, 200 patients were chosen according to inclusion and exclusion criteria. RESULTS Out of 25, thirteen of our patients were male and twelve were female, for a ratio of 58% males to 42% females. 40% of the patients in our research were between 1 and 24 months of age. 60% were offspring of non-consanguineous marriage. Positive patients who were married consanguineously were third-degree relatives. During the course of our investigation, we discovered that the majority of patients were from Kupwara, totaling 25% of the study group. In our study, 72% of patients presented with recurrent respiratory tract infections. CONCLUSION In our study we concluded that Cystic brosis in Kashmir is more prevalent in men with non-consanguineous marriages and in the Kupwara district.