Abstract

Immunity to viruses that replicate in insect hosts is of interest from both basic and applied perspectives in terms of (1) increased understanding of fundamental processes involved in anti-viral immunity and viral counter-measures, (2) use of this knowledge to facilitate the means by which arthropod-borne viruses (arboviruses) of vertebrate hosts can be managed, and (3) exploitation of strategies used by viruses to overcome physiological barriers for pest management purposes. In this chapter, we review the anti-viral mechanisms against viruses that replicate in insects, including genetic resistance, physical and physiological barriers to infection, cellular and subcellular inhibition, humoral immunity and developmental resistance, and finally highlight some practical applications of this knowledge for management of agricultural pests and vector-borne disease.

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