Abstract
Background and Aims: This study aims at determining the demographic profile and extra-intestinal manifestations of Ulcerative Colitis in the Nepalese patients treated in a tertiary referral centre.Methods: The study was conducted between February 1, 2014 and January 31, 2015 at the Department of Gastroenterology Tribhuvan University Teaching Hospital, Kathmandu, Nepal. The clinical and epidemiologic data from patients diagnosed to have Ulcerative Colitis were obtained and analysed.Results: During the study period, 60 patients were identified as having ulcerative colitis. Mean age at diagnosis was 34.6 years. The mean duration of illness at diagnosis was 3.7 years. Extra-intestinal manifestations (EIM) were seen in 16.6% of the patients. Sacroilitis was the most common EIM seen in11.6% followed by peripheral arthritis in 6.6% of the patients. Episcleritis, Primary Sclerosing Cholangitis and Erythema Nodosum were seen only in 1.6% each. At the time of presentation, 38.3% (n=23) had proctosigmoiditis , 50% (n=30) left sided colitis and pancolitis was seen in 11.7% (n=7).53.3% patients had mild disease, 38.3% and 8.3 % presented with moderate to severe disease respectively.Conclusion: Peak age of onset for UC in the study was third and fourth decade which was similar to the various studies from Asia and West. Musculoskeletal manifestation was the most common extra- intestinal manifestation of UC in Nepalese population. As Nepal is perhaps the most diverse country in terms of ethnicity, cultural variation, socio-economic status and health care facilities, a comprehensive nationwide data bank involving ethnicity and geographical variation is needed for a better definition of the disease characteristics.Journal of Advances in Internal Medicine 2015;04(01):1-5.
Highlights
IntroductionUlcerative colitis is a chronic inflammatory bowel disease of unknown etiology
Our study showed majority of disease is left sided colitis 50% and 11.7% of patient diagnosed as Pancoliitis whereas reports from western countries shows 27–62.7% of patients suffering from pancolitis
Peak age of onset for Ulcerative Colitis in this study was found to be in the 3rd&4th decade which was similar to the various studies reported from Asia and Western countries
Summary
Ulcerative colitis is a chronic inflammatory bowel disease of unknown etiology. It is a worldwide disorder with significant geographical heterogeneity, the highest prevalence rates having been reported from Northern and Western Europe and North America.[1] A significant North-South gradient has these premises. This study aims at determining the demographic profile and extra-intestinal manifestations of Ulcerative Colitis in the Nepalese patients treated in a tertiary referral centre. The clinical and epidemiologic data from patients diagnosed to have Ulcerative Colitis were obtained and analysed. Mean age at diagnosis was 34.6 years. Extra-intestinal manifestations (EIM) were seen in 16.6% of the patients. As Nepal is perhaps the most diverse country in terms of ethnicity, cultural variation, socio-economic status and health care facilities, a comprehensive nationwide data bank involving ethnicity and geographical variation is needed for a better definition of the disease characteristics
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