Abstract
In September, 1959, a new tetracycline compound, demethylchlortetracycline*(here-after referred to as DMCT), became available for general use. This compound is reported to be identical in structure to chlortetracycline except for the absence of a methyl group in the 6-position.1In early studies it was found to be more resistant to acid and alkali degradation than the other tetracyclines in common use,1and to be generally more active against bacterial pathogens than tetracycline (hereafter referred to as TC) or oxytetracycline.2-5The amount of DMCT absorbed from the gastrointestinal tract of man following a single dose was less than with TC,6,11but Kunin and Finland found that the serum half-life was 44% greater for DMCT than for TC, and the renal clearance of the former drug was only 43% of the latter.7Assays of serum antibacterial activity after equal doses of the 2 drugs showed significantly
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
