Abstract
Demetalation kinetics of zinc chlorophyll derivative 1 possessing two formyl groups directly linked to the A- and B-rings of the chlorin macrocycle, which was synthesized from chlorophyll b, was examined under acidic conditions and compared with those of Zn chlorins 2 and 3 possessing a single formyl group in the A- and B-ring, respectively, as well as Zn chlorin 4 lacking any formyl group to unravel the substitution effects on demetalation properties of chlorophyllous pigments. Demetalation kinetics of diformylated Zn chlorin 1 was slower than those of monoformylated Zn chlorins 2 and 3, indicating that the effect of the electron-withdrawing formyl group on demetalation kinetics was amplified by introduction of two formyl groups to the chlorin macrocycle. High correlations were observed between demetalation rate constants of Zn chlorins 1–4 and the sum of Hammett σ parameters of the 3- and 7-substituents on the chlorin macrocycle, indicating that the combination of electron-withdrawing abilities of the substituents linked directly to the cyclic tetrapyrrole was responsible for demetalation properties of zinc chlorophyll derivatives.
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