Abstract
It is important to have a wide perspective to provide appropriate medical care for the oldest-old individuals. In terms of daily clinical practice, polypharmacy is an important factor that affects cognitive decline in older adults. The neuropathologic changes of dementia in the oldest-old individuals are associated with Alzheimer's disease, Lewy body disease, cerebrovascular disease, primary age-related tauopathy (PART), limbic-predominant age-related TDP-43 encephalopathy (LATE), and aging-related tau astrogliopathy (ARTAG).
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