Abstract
Dementia of frontal lobe type may precede motor signs in a number of adult patients with amyotrophy. Neuropathological studies have shown neuron loss, spongiosis and gliosis mainly in layers II and III of the frontal and temporal lobes, together with myelin pallor of the subcortical white matter. Golgi studies revealed loss of dendritic spines on the apical dendrite of layer III pyramidal neurons, decreased numbers of dendrites, amputation and tortuosities of dendrites, and distal and proximal dendritic swellings and enlargements. Calbindin D-28K immunocytochemistry revealed a marked decrease in the number of cortical immunoreactive neurons and loss of immunoreactivity in dendrites of the remaining cells. These features indicate that pyramidal and non-pyramidal neurons in layers II and III are severely damaged, and suggest that cortical processing is seriously impaired in patients with frontal lobe type dementia.
Highlights
FerrerUnidad de Neuropatologfa, Servicio de Anatomfa Patol6gica, Hospital Prfncipes de Espana, Universidad de Barcelona, 08907 Hospitalet de L/obregat, Barcelona, Spain
Motor neuron disease associated with dementia and Parkinsonism is common in distinct populations of the Mariana Islands, New Guinea and the Kii Peninsula of Honshu Island
In this study we have focused our attention on the abnormalities in the cerebral cortex in patients with frontal lobe type dementia and amyotrophy in an attempt to learn the morphological substrates of this type of dementia
Summary
Unidad de Neuropatologfa, Servicio de Anatomfa Patol6gica, Hospital Prfncipes de Espana, Universidad de Barcelona, 08907 Hospitalet de L/obregat, Barcelona, Spain. Dementia of frontal lobe type may precede motor signs in a number of adult patients with amyotrophy. Golgi studies revealed loss of dendritic spines on the apical dendrite oflayer III pyramidal neurons, decreased numbers of dendrites, amputation and tortuosities of dendrites, and distal and proximal dendritic swellings and enlargements. Calbindin D·28K immunocytochemistry revealed a marked decrease in the number of cortical immunoreactive neurons and loss of immunoreactivity in dendrites of the remaining cells. These features indicate that pyramidal and non·pyramidal neurons in layers II and III are severely damaged, and suggest that cortical processing is seriously impaired in patients with frontal lobe type dementia
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