Abstract
Objective: Our goal is to evaluate the safety of demcizumab (DLL4 targeted IgG2 humanized monoclonal antibody; potent inhibitor of the Notch pathway) in combination with weekly paclitaxel in platinum-resistant EOC; to estimate the maximum tolerated dose (MTD) or maximum administered dose (MAD); and to determine the recommended phase two dose. Objective response rate (ORR) was a secondary objective.
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