Delivery Systems for Flavors and Fragrances: Quality by Design-Based Considerations

Abstract

Flavors and fragrances are volatile components with a wide range of applications in medicine, cosmetics, food, textiles, and other fields. However, their short shelf life owing to evaporation and component degradation prior to or during use makes them challenging to use. This chapter examined published studies and insights on nanoplatforms and the encapsulation of Flavor and fragrances into carriers, focusing on the scientific issues faced by these volatile encapsulants. Fragrances and Flavors have a longer shelf life when they are encapsulated. The coating acts as a protective barrier, increasing molecular stability and facilitating delayed or controlled delivery techniques. Many consumer items customize the release and delivery of Flavor and scents using encapsulation. For the delivery of fragrances and Flavors, several delivery systems such as microparticles, nanoparticles, and liposomes are being investigated. In addition, the selected nanoformulations have a thorough comprehension of several elements of Quality-by-Design principles, such as the determination of critical materials, process parameters, and quality attributes. Risk alignment for assessing the probable elements that impact the quality of profile of the target formulations, as well as important features of quality risk management techniques like Ishikawa fishbone diagram and risk assessment matrix for nanoproducts are also covered. Owing their small size, nanoformulations increase macroscale qualities such as texture, Flavor, and Color, as well as the taste and scent properties of items during preservation. These platforms may be researched and improved for efficient Flavor and aroma medication delivery.