Abstract
Physically loading of paclitaxel (PTX) onto carbon nanotubes (CNTs) is achieved throughimmersion of poly(ethylene glycol) (PEG)-graft-single walled CNTs (PEG-g-SWNTs)or PEG-graft-multi-walled CNTs (PEG-g-MWNTs) in a saturated solution ofPTX in methanol. After loading once the loading capacity (LD%) is 26% (w/w) and36% (w/w) for PEG-g-SWNTs or PEG-g-MWNTs, respectively. With these PTX contents, PTXloaded PEG-g-SWNTs and PTX loaded PEG-g-MWNTs still have good dispersity inaqueous solution and individual CNTs can be observed in TEM images. PTX can bereleased from PEG-g-CNTs several times faster than from free PTX but still in a sustainedprofile with less than 40% of PTX being released in 40 days at pH 7 or 5. In vitrocytotoxicity of samples is evaluated in HeLa cells and MCF-7 cells. PEG-g-SWNTs andPEG-g-MWNTs show low cytotoxicity in both cells with insignificant effects on the cellproliferation rates. However, both PTX loaded PEG-g-SWNTs and PTX loadedPEG-g-MWNTs show high efficacy to kill HeLa cells and MCF-7 cells, as reflected byIC50 lower than free PTX. Therefore, PTX loaded PEG-g-CNTs are promising for cancertherapeutics. Keywords: carbon nanotubes, poly(ethylene glycol), drug delivery, cancertherapy, nanomedicine.
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